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Search Results for " hiv integrase "

45

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11566	HIV-1 integrase inhibitor	Others	Others
	Hiv-1 integrase inhibitor is an effective anti-HIV drug.
T4182	lavendustin B 薰草菌素B	Tyrosinase; transporter; HIV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Lavendustin B 是一种酪氨酸激酶抑制剂，是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。
T11565	HIV-1 integrase inhibitor 7	Others	Others
	HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM).
T11568	HIV-1 integrase inhibitor 4	Others	Others
	HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM).
T11567	HIV-1 integrase inhibitor 3	Others	Others
	HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM).
T4493	Bictegravir GS-9883	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bictegravir (GS-9883) 是一种 HIV-1 整合酶抑制剂，其IC50值为 7.5 nM。
T2239L	Raltegravir 雷特格韦,MK-0518	HIV Protease; Integrase	Microbiology/Virology; Proteases/Proteasome
	Raltegravir (MK-0518) 是一种HIV 整合酶抑制剂。
T0753	Salicylanilide WR10019,2-Hydroxybenzanilide,水杨酰苯胺	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Salicylanilide (2-Hydroxybenzanilide) 有广泛的生物学特性，如抗病毒、菌和抗真菌活性。
T60742	HIV-1 integrase inhibitor 8	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 integrase inhibitor 8 是一种 HIV-1 整合酶抑制剂，整合是HIV 复制的必要步骤。
T2332	Elvitegravir 埃替格韦,GS-9137,EVG,D06677,JTK-303	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Elvitegravir (JTK-303) 是一种人类免疫缺陷病毒整合酶链转移抑制剂，作用于 HIV-1IIIB、HIV-2EHO 和 HIV-2ROD，IC50分别为 0.7 nM、2.8 nM 和 1.4 nM。
T2329	Dolutegravir sodium 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir sodium (GSK-1349572A) 是一种高效、口服的 HIV 整合酶链转移抑制剂，在 HIV-1 整合酶催化的链转移中的 IC50值为 2.7 nM，抑制 HIV-1 病毒在外周血单个核细胞中的复制，IC50为 0.51 nM。它对 Y143R，N155H 和 G140S/Q148H 突变体也保持高效。
T6420	BMS-707035 N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS707035是一种 HIV-1 整合酶抑制剂，IC50为15 nM。
T2239	Raltegravir potassium MK 0518 potassium salt,Raltegravir potassium salt,雷特格韦钾盐	HIV Protease; Integrase	Microbiology/Virology; Proteases/Proteasome
	Raltegravir potassium (MK 0518 potassium salt) 是一种整合酶抑制剂，用于研究 HIV 感染。
T9854	HIV-1 inhibitor-6 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂，可以阻断HIV 复制。
T6198	Dolutegravir S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir (GSK1349572) 是口服HIV 整合酶链转移高效抑制剂，抑制 HIV-1 病毒在外周血单个核细胞中的复制。它对耐拉替拉韦的特征突变体 Y143R、Q148K、N155H 和 G140S/Q148H 具有中等活性。
T15483	LEDGIN6 HIV-1 integrase inhibitor 2	Others	Others
	HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.
T6098	Cabotegravir GSK744,GSK-1265744,卡博特韦,S/GSK1265744	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂，可研究艾滋病。它抑制OAT1 和OAT3，IC50值为 0.81 和0.41 μM。
T62156	HIV-1 integrase inhibitor 9
	HIV-1 integrase inhibitor 9 (compound 8a) 是一种 HIV-1 RNase H 的有效抑制剂 (IC50: 12.3 μM)，具有抗病毒作用。
T72162	HIV-1 integrase inhibitor 10
	HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI)，具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长，其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。
T6589	MK-2048 MK2048	HIV Protease; Integrase	Microbiology/Virology; Proteases/Proteasome
	MK-2048是HIV 整合酶和INR263K 的抑制剂，IC50分别为2.6 nM 和1.5 nM。
T35340	Bictegravir Sodium GS-9883 Sodium	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bictegravir Sodium (GS-9883 Sodium) 是一种有效的 HIV-1 整合酶抑制剂，其 IC50 值为 7.5 nM。Bictegravir Sodium 表现出强大的选择性的抗 HIV 活性和低的细胞毒性。
T30479	Bis-T-23 Bis T-23,Bis-T 23,AG1717	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Bis-T-23是一种肌动蛋白依赖性达纳敏低聚物的促进剂，是一种 HIV-I 整合酶抑制剂，是泰尔普斯丁衍生物。Bis-T-23可以促进肌动蛋白依赖性的dynamin 寡聚化。Bis-T-23可用于HIV 和慢性肾脏疾病（CKD）的研究。
T11074	Dolutegravir intermediate-1 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) 是 Dolutegravir 的一种新合成中间体。它是一种整合酶抑制剂，有潜力研究人类免疫缺陷病毒 (HIV)-1 感染。
T39755	Pirmitegravir STP0404	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Pirmitegravir (STP0404) 是一种针对 LEDGF/p75 结合位点的异位整合酶（ALLINI）的强效选择性抑制剂。 Pirmitegravir 可抑制 PBMC。 Pirmitegravir 具有显著的抗病毒活性，可用于研究 HIV 病毒感染。
T16829	(S)-BI-1001	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T24752	S-1360 GW810781,GW-810781,GSK-S-1360,S1360,S 1360
	S-1360 is an inhibitor of HIV-1 integrase.
T31125	CX14442 Sodium
	Cx14442 sodium is a new effective HIV-1 integrase inhibitor.
T19670	BMS-538203
	BMS-538203 is a novel HIV integrase inhibitor.
T68414	5-ClTEP
	5-ClTEP is a HIV-1 integrase inhibitor.
T73524	XZ426
	XZ426 是一种有效的整合酶链转移抑制剂，具有抗HIV 活性。
T79021	GSK3839919A
	GSK3839919A为高效HIV-1整合酶抑制剂。
T64096	Integrase-LEDGF/p75 allosteric inhibitor 1
	Integrase-LEDGF/p75 allosteric inhibitor 1 是一种口服具有活力的 integrase-LEDGF/p75 (IN-LEDGF/p75) 变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 能够抑制 HIV-1 DNA 整合，表现出抗病毒作用，能够作用于 HIV-1重组分子克隆 NL432 (EC50: 3.9 nM)。
T14559	BI 224436	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
T36793	Dolutegravir M1
	Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1. 1.Zhu, J., Wang, P., Li, F., et al.CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitorBiochem. Pharmacol.158174-184(2018)
T24366	L 870810 L-870,810,L870810,L 870,810,L870,810,L-870810
	L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.
T28811	SM111 SM 111,SM-111
	SM111 inhibits in vitro replication of HIV-1, including strains resistant to reverse transcriptase, licensed protease, and integrase inhibitors, without major cellular toxicity.
T62983	Raltegravir sodium
	Raltegravir (MK 0518) sodium 是一种有效的、口服具有活力的 HIV 整合酶（IN）抑制剂。
T68364	GS-9160
	GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease of integration junctions.
T70791	GSK-1264
	GSK-1264 is an allosteric inhibitor of human immunodeficiency virus (HIV) integrase which blocks viral replication and abnormal multimerization involving specific protein domains.
T70881	Dolutegravir RR Isomer
	Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T63977	GSK3739936
	GSK3739936 是 HIV-1 变构整合酶 (HIV-1 allosteric integrase) 的有效抑制剂 (IC50: 11.1 nM, EC50: 1.7 nM)。GSK3739936 也是一种 CYP 的弱抑制剂，其IC50>24.3 μM。GSK3739936 在实验动物中具有良好的药代动力学特性，吸收快、清除率低至中等，以及口服生物利用度良好。
T71009	Dolutegravir SR Isomer
	Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T36794	Dolutegravir O-β-D-Glucuronide
	Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544...
T62328	Cabotegravir sodium
	Cabotegravir sodium 是一种 HIV 整合酶的高效抑制剂，能够作用于 HIVADA (IC50: 2.5 nM)。Cabotegravir sodium 主要由尿苷二磷酸葡萄糖醛酸转移酶 (UGT) 1A1 代谢，与其他抗逆转录病毒药物 (ARVs) 相互作用的可能性较小。
T37713	Funalenone
	Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits...

化合物

HIV-1 integrase inhibitor

Cat.No: T11566

Target: Others

Cat.No: T4182

Synonym: 薰草菌素B

Target: Tyrosinase, transporter, HIV Protease

HIV-1 integrase inhibitor 7

Cat.No: T11565

Target: Others

HIV-1 integrase inhibitor 4

Cat.No: T11568

Target: Others

HIV-1 integrase inhibitor 3

Cat.No: T11567

Target: Others

Cat.No: T4493

Synonym: GS-9883

Target: HIV Protease

Cat.No: T2239L

Synonym: 雷特格韦,MK-0518

Target: HIV Protease, Integrase

Cat.No: T0753

Synonym: WR10019,2-Hydroxybenzanilide,水杨酰苯胺

Target: HIV Protease, Reverse Transcriptase

HIV-1 integrase inhibitor 8

Cat.No: T60742

Target: HIV Protease

Cat.No: T2332

Synonym: 埃替格韦,GS-9137,EVG,D06677,JTK-303

Target: HIV Protease

Dolutegravir sodium

Cat.No: T2329

Synonym: 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A

Target: HIV Protease

Cat.No: T6420

Synonym: N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺

Target: HIV Protease

Raltegravir potassium

Cat.No: T2239

Synonym: MK 0518 potassium salt,Raltegravir potassium salt,雷特格韦钾盐

Target: HIV Protease, Integrase

HIV-1 inhibitor-6

Cat.No: T9854

Synonym: 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-

Target: HIV Protease

Cat.No: T6198

Synonym: S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦

Target: HIV Protease

Cat.No: T15483

Synonym: HIV-1 integrase inhibitor 2

Target: Others

Cat.No: T6098

Synonym: GSK744,GSK-1265744,卡博特韦,S/GSK1265744

Target: HIV Protease

HIV-1 integrase inhibitor 9

Cat.No: T62156

HIV-1 integrase inhibitor 10

Cat.No: T72162

Cat.No: T6589

Synonym: MK2048

Target: HIV Protease, Integrase

Bictegravir Sodium

Cat.No: T35340

Synonym: GS-9883 Sodium

Target: HIV Protease

Cat.No: T30479

Synonym: Bis T-23,Bis-T 23,AG1717

Target: HIV Protease

Dolutegravir intermediate-1

Cat.No: T11074

Synonym: 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Target: HIV Protease

Cat.No: T39755

Synonym: STP0404

Target: HIV Protease

Cat.No: T16829

Target: HIV Protease

Cat.No: T24752

Synonym: GW810781,GW-810781,GSK-S-1360,S1360,S 1360

Cat.No: T31125

Cat.No: T19670

Cat.No: T68414

Cat.No: T73524

Cat.No: T79021

Integrase-LEDGF/p75 allosteric inhibitor 1

Cat.No: T64096

Cat.No: T14559

Target: HIV Protease

Dolutegravir M1

Cat.No: T36793

Cat.No: T24366

Synonym: L-870,810,L870810,L 870,810,L870,810,L-870810

Cat.No: T28811

Synonym: SM 111,SM-111

Raltegravir sodium

Cat.No: T62983

Cat.No: T68364

Cat.No: T70791

Dolutegravir RR Isomer

Cat.No: T70881

Cat.No: T63977

Dolutegravir SR Isomer

Cat.No: T71009

Dolutegravir O-β-D-Glucuronide

Cat.No: T36794

Cabotegravir sodium

Cat.No: T62328

Cat.No: T37713

Cat. No.	Product Name	Target	Signaling Pathways
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
TN2158	Robinetin 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素	Anti-infection; HIV Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显著的“两种颜色”固有荧光特性。它具有抗真菌、抗病毒、抗菌、抗突变、抗氧化和抗自由基活性，高效抑制 EYPC 膜脂质过氧化和 HbA 糖基化。
TL0006	Cichoric Acid 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物，具有抗氧化作用。
T2S1158	4,5-Dicaffeoylquinic acid 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C	Others; HBV; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物，有抗病毒、抗肝毒性活性。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
TN6518	4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol
	4,4-di(4-Hydroxy-3-methoxyphenly)-2,3-dimethylbutanol has antioxidant and potential cytotoxic abilities, it also shows inhibition against HIV-1 integrase.
T11219	Equisetin	Others	Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...
T79967	Dihydroobionin B
	Dihydroobionin B作为一种HIV-1 Integrase抑制剂显示出高效性，其对HIV1型整合酶具有显著抑制作用，IC50值为0.44 μM，且未表现出显著的细胞毒性。
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...

天然产物

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Cat.No: TN2158

Synonym: 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素

Target: Anti-infection, HIV Protease, Antibacterial

Cat.No: TL0006

Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

4,5-Dicaffeoylquinic acid

Cat.No: T2S1158

Synonym: 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C

Target: Others, HBV, Endogenous Metabolite

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol

Cat.No: TN6518

Cat.No: T11219

Target: Others

Dihydroobionin B

Cat.No: T79967

3-Hydroxyterphenyllin

Cat.No: T36000

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